Mac and Cheese Meatloaf Casserole: The Ultimate Comfort Food Mashup
If you’re looking for the ultimate comfort food mashup, you’ve come to the right place! This Mac and Cheese Meatloaf Casserole is a warm hug in a dish. It combines the creamy goodness of macaroni and cheese with the savory heartiness of meatloaf, making it a favorite in my home. Perfect for busy weeknights or family gatherings, this casserole is sure to please even the pickiest eaters.
The best part? It’s simple to make and packed with flavor! You’ll love how easy it is to bring everyone together around the dinner table with this delicious meal.
Why You’ll Love This Recipe
- Easy to Prepare: With just a few steps, you can whip up this comforting dish without spending all day in the kitchen.
- Family-Friendly Appeal: Everyone loves mac and cheese, and when paired with meatloaf, it becomes an instant hit for all ages!
- Make-Ahead Convenience: You can prepare it ahead of time and pop it in the oven when you’re ready to eat.
- Deliciously Flavorful: The combination of cheesy goodness and savory meatloaf creates a flavor explosion that will have your taste buds dancing.
- Versatile: Feel free to customize it with your favorite ingredients or variations!

Ingredients You’ll Need
These are simple, wholesome ingredients that you might already have in your pantry. Let’s gather everything we need for this delightful casserole.
For the Meatloaf
- Ground Beef: 1 lb
- Onion: 1/2 cup, diced
- Breadcrumbs: 1/2 cup
- Egg: 1 large
- Milk: 1/4 cup
- Salt: 1 tsp
- Pepper: 1/2 tsp
For the Mac and Cheese
- Macaroni: 2 cups, uncooked
- Cheddar Cheese: 2 cups, shredded
- Butter: 2 tbsp
- Flour: 2 tbsp
- Milk: 2 cups
- Salt: 1/2 tsp
- Pepper: 1/4 tsp
- Paprika: 1/2 tsp
- Dry Mustard: 1/2 tsp
Variations
This Mac and Cheese Meatloaf Casserole is so flexible! You can easily switch up ingredients to suit your taste or what you have on hand.
- Swap the protein: Use ground turkey or chicken instead of beef for a lighter option.
- Add veggies: Toss in some spinach or broccoli for added nutrition and color.
- Change the cheese: Experiment with different cheeses like mozzarella or pepper jack for a fun twist on flavor.
- Spice it up: Add some hot sauce or diced jalapeños to give your casserole an extra kick!
How to Make Mac and Cheese Meatloaf Casserole: The Ultimate Comfort Food Mashup
Step 1: Preheat Your Oven
Preheat your oven to 350°F (175°C). This ensures that your casserole bakes evenly and comes out perfectly melted and bubbly.
Step 2: Prepare the Meatloaf
In a large bowl, combine the ground beef, diced onion, breadcrumbs, egg, milk, salt, and pepper. Mix well until everything is evenly combined. Press this mixture into the bottom of a greased 9×13-inch baking dish. This forms the hearty base of your casserole.
Step 3: Bake the Meatloaf
Pop the meatloaf into your preheated oven and bake for about 20 minutes. This gives it a head start on cooking before we add all that delicious mac and cheese.
Step 4: Cook the Macaroni
While your meatloaf is baking, cook the macaroni according to package directions. Drain it well and set aside. This step keeps everything nice and cohesive when layering.
Step 5: Make the Cheese Sauce
In a saucepan over medium heat, melt the butter. Once melted, stir in flour and cook for about a minute. Gradually whisk in milk until thickened. Stir in salt, pepper, paprika, dry mustard, and then fold in 1½ cups of shredded cheese until everything is melted together beautifully.
Step 6: Combine Everything
Stir the cooked macaroni into your creamy cheese sauce until well coated. Pour this cheesy goodness over the partially baked meatloaf layer in your dish. Top off with any remaining cheese for that ooey-gooey finish!
Step 7: Bake Again
Return your masterpiece to the oven and bake for an additional 25 minutes or until it’s golden brown and bubbly on top. The aroma will fill your home with warmth as you wait!
And there you have it! A delicious Mac and Cheese Meatloaf Casserole that’s sure to become a staple at your dinner table. Enjoy!
Pro Tips for Making Mac and Cheese Meatloaf Casserole: The Ultimate Comfort Food Mashup
Creating the perfect Mac and Cheese Meatloaf Casserole is all about those little touches that elevate the dish. Here are some handy tips to ensure your casserole turns out amazing!
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Use Fresh Ingredients: Fresh ingredients can make a big difference in flavor. Opt for freshly shredded cheese instead of pre-packaged to avoid additives and enhance creaminess.
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Don’t Overcook the Macaroni: Since the macaroni will continue cooking in the oven, cooking it just until al dente will prevent it from becoming mushy in the casserole.
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Experiment with Cheese Varieties: While cheddar is classic, mixing in other cheeses like mozzarella or pepper jack can add exciting flavors and textures to your cheesy layer.
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Let It Rest Before Serving: Allowing the casserole to sit for about 10 minutes after baking helps it set up nicely, making it easier to cut into neat squares for serving.
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Add Some Spice: If you’re feeling adventurous, sprinkle in some crushed red pepper flakes or a dash of hot sauce into the cheese sauce for an extra kick that complements the savory meatloaf.
How to Serve Mac and Cheese Meatloaf Casserole: The Ultimate Comfort Food Mashup
Serving up this delightful casserole can be as fun as making it! With its layers of luscious cheese and hearty meatloaf, you’ll definitely want to showcase this dish at the dinner table.
Garnishes
- Chopped Fresh Parsley: A sprinkle of fresh parsley adds a pop of color and a refreshing taste that balances the richness of the casserole.
- Crushed Crackers or Chips: For added crunch, top with some crushed buttery crackers or tortilla chips before serving, giving each bite a satisfying texture contrast.
Side Dishes
- Steamed Broccoli: This vibrant green veggie adds a nutritious element while its slight bitterness pairs perfectly with the creamy casserole.
- Garden Salad: A light salad with mixed greens, tomatoes, cucumbers, and a tangy vinaigrette provides a refreshing contrast to the richness of your dish.
- Roasted Vegetables: Seasonal roasted veggies like carrots, zucchini, and bell peppers bring out natural sweetness that complements the savory flavors of your casserole.
- Garlic Bread: A warm slice of garlic bread on the side makes for an irresistible combination—perfect for scooping up any extra cheesy goodness!
This Mac and Cheese Meatloaf Casserole is sure to become a family favorite, bringing everyone together over hearty flavors and comforting textures. Enjoy every delicious bite!

Make Ahead and Storage
This Mac and Cheese Meatloaf Casserole is perfect for meal prep, making it a fantastic option for busy weeknights or when you want to have leftovers on hand. Here’s how to store and preserve the deliciousness!
Storing Leftovers
- Allow the casserole to cool completely before storing.
- Transfer leftovers to an airtight container.
- Store in the refrigerator for up to 3 days.
Freezing
- Wrap individual portions or the entire casserole tightly in plastic wrap, then aluminum foil.
- Label with the date and freeze for up to 2 months.
- When ready to eat, thaw overnight in the refrigerator before reheating.
Reheating
- Preheat your oven to 350°F (175°C).
- If frozen, thaw overnight in the fridge before reheating.
- Place the casserole in an oven-safe dish, cover with foil, and heat for about 20-25 minutes until warmed through.
- For a crispy top, remove the foil during the last 5-10 minutes of heating.
FAQs
Here are some common questions about this delightful dish!
Can I use ground turkey instead of beef in Mac and Cheese Meatloaf Casserole?
Absolutely! Ground turkey is a great alternative that will still keep your casserole moist and flavorful.
How long does it take to make Mac and Cheese Meatloaf Casserole?
The total cooking time is about 1 hour, making it a quick yet hearty meal option for any day of the week.
Can I make Mac and Cheese Meatloaf Casserole ahead of time?
Yes! You can prepare it ahead and store it in the fridge or freezer. Just follow the storage instructions above.
What type of cheese works best in this casserole?
While cheddar is traditional, feel free to mix it up with mozzarella or pepper jack for added flavor!
Is this recipe suitable for kids?
Definitely! This comforting dish combines familiar flavors that appeal to both kids and adults alike.
Final Thoughts
I hope you’re as excited as I am about trying out this Mac and Cheese Meatloaf Casserole! It truly brings together two beloved dishes into one delectable meal that’s sure to please everyone at your table. Enjoy making this special recipe, and don’t forget to share it with friends and family who might need a dose of comfort food. Happy cooking!
Mac and Cheese Meatloaf Casserole: The Ultimate Comfort Food Mashup
If you’re craving comfort food that delivers on flavor and satisfaction, look no further than this Mac and Cheese Meatloaf Casserole. This heartwarming dish combines the rich, creamy goodness of macaroni and cheese with the savory, satisfying texture of meatloaf. Perfect for busy weeknights or family gatherings, this casserole is an instant favorite that even picky eaters will love. With its easy preparation and delightful taste, it’s a fantastic way to bring everyone together around the dinner table.
- Prep Time: 15 minutes
- Cook Time: 45 minutes
- Total Time: 1 hour
- Yield: Serves 8
- Category: Main
- Method: Baking
- Cuisine: American
Ingredients
- 1 lb Ground Beef
- 1/2 cup Onion, diced
- 1/2 cup Breadcrumbs
- 1 large Egg
- 1/4 cup Milk
- 1 tsp Salt
- 1/2 tsp Pepper
- 2 cups Macaroni, uncooked
- 2 cups Cheddar Cheese, shredded
- 2 tbsp Butter
- 2 tbsp Flour
- 2 cups Milk
- 1/2 tsp Salt
- 1/4 tsp Pepper
- 1/2 tsp Paprika
- 1/2 tsp Dry Mustard
Instructions
- Preheat your oven to 350°F (175°C).
- In a bowl, mix ground beef, diced onion, breadcrumbs, egg, milk, salt, and pepper. Press into a greased 9×13-inch baking dish.
- Bake the meatloaf for about 20 minutes.
- While baking, cook macaroni according to package directions; drain.
- In a saucepan over medium heat, melt butter, add flour and whisk in milk until thickened. Stir in seasonings and cheese until melted.
- Combine macaroni with cheese sauce and pour over the meatloaf layer. Top with remaining cheese.
- Bake for an additional 25 minutes until golden brown.
Nutrition
- Serving Size: 1/8 of the casserole (approximately 250g)
- Calories: 520
- Sugar: 6g
- Sodium: 620mg
- Fat: 26g
- Saturated Fat: 12g
- Unsaturated Fat: 12g
- Trans Fat: 0g
- Carbohydrates: 48g
- Fiber: 3g
- Protein: 30g
- Cholesterol: 90mg
